Scientific Reports
2024 | |
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Abstract Full article | De Genna NM, Jacobsen E, Ganguli M. Marijuana use among community-dwelling older adults: A population-based study. Int J Geriatr Psychiatry. 2024 Apr;39(4):e6086. doi: 10.1002/gps.6086. PMID: 38613138. |
Zhang Y, Ferreira PCL, Jacobsen E, Bellaver B, Pascoal TA, Snitz BE, Chang C-C H, Villemagne VL, Ganguli M, Karikari T. Association of plasma biomarkers of Alzheimer’s disease and related disorders with cognition and cognitive decline: a population-based study. Alzheimer’s & Dementia, in press. PMC in process. |
2023 | |
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Abstract Full Article | Gonzalez-Ortiz, F., Ferreira, P. C. L., González-Escalante, A., Montoliu-Gaya, L., Ortiz-Romero, P., Kac, P. R., Turton, M., Kvartsberg, H., Ashton, N. J., Zetterberg, H., Harrison, P., Bellaver, B., Povala, G., Villemagne, V. L., Pascoal, T. A., Ganguli, M., Cohen, A. D., Minguillon, C., Contador, J., Suárez-Calvet, M., … Blennow, K. (2024). A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 20(2), 1239–1249. https://doi.org/10.1002/alz.13525; PMID 37975513; PMCID 10916963 |
Abstract Full Article | Fang, F., Hughes, T. F., Weinstein, A., Dodge, H. H., Jacobsen, E. P., Chang, C. H., Snitz, B. E., & Ganguli, M. (2023). Social Isolation and Loneliness in a Population Study of Cognitive Impairment: The MYHAT Study. Journal of applied gerontology : the official journal of the Southern Gerontological Society, 42(12), 2313–2324. https://doi.org/10.1177/07334648231192053; PMID:37518906, PMCID 10825064 |
Abstract | Teverovsky EG, Gildengers A, Ran X, Jacobsen E, Chang C-C H, Ganguli M. Benzodiazepine use and risk of incident MCI and dementia in a community sample. International Psychogeriatrics, 2023, ePub DOI: https://doi.org/10.1017/S1041610223000455 PMID 37231775, NIHMSID 1904514, PMC in process. |
Bellaver B, Povala G, Ferreira PCL,……Karikari TK, Rosa-Neto P, Pascoal TA. Astrocyte reactivity influences the association of amyloid-β and tau biomarkers in preclinical Alzheimer’s disease. Nature Medicine, in press. PMC in process. | |
Abstract | Jain N, Wang Y, Zhang Y, Jacobsen E, Andreescu C, Snitz BE, Chang C-C H, Ganguli M. It goes both ways: The relationship between anxiety and mild cognitive impairment. International Journal of Geriatric Psychiatry, 2023, e5899, ePub http://doi.org/10.1002/gps.5899 PMID:36855309 PMC in process. |
Abstract | Ferreira PCL, Zhang Y, Snitz B, Chang C-C H, Bellaver B, Jacobsen EP, Kamboh MI, Zetterberg H, Blennow K, Pascoal T, Villemagne V, Ganguli M, Karikari T. Plasma biomarkers identify older adults at risk of Alzheimer’s disease and related dementias in a real-world population cohort. Alzheimer’s & Dementia, 2023, in press. PMC in process. |
Abstract Full Article | Gildengers AG, Stoehr GP, Ran X, Jacobsen EP, Teverovsky EG, Chang C-C H, Ganguli M. Anticholinergic drug burden and risk of incident MCI and dementia –A Population-Based Study. Alzheimer’s Disease and Associated Disorders, 2022, DOI: 10.1097/WAD.0000000000000538, PMID: 36706325; PMCID 9974875 |
Abstract Full Article | Wood I, Bhojak T, Jia Y, Jacobsen EP, Snitz BE, Chang C-C H, Ganguli M. Predictors of driving cessation in older adults: A 12-year population-based study. Alzheimer’s Disease and Associated Disorders, 2022, DOI: 10.1097/WAD.0000000000000541, PMID: 36706321; PMCID 9974810 |
Abstract | Acharya V, Fan KH, Snitz BE, et al. Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19-related gene for global cognitive function [published online ahead of print, 2023 Apr 23]. Alzheimers Dement. 2023;10.1002/alz.13064. PMID: 37089073; doi:10.1002/alz.13064 |
2022 | |
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Abstract Full Article | Fan, K., Francis, L., Aslam, M. M., Bedison, M. A., Lawrence, E., Acharya, V., Snitz, B. E., Ganguli, M., DeKosky, S. T., Lopez, O. L., Feingold, E., & Kamboh, M. I. (2023). Investigation of the independent role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late-onset Alzheimer disease. Neurobiology of aging, 122, 107–111. PMID: 36528961; PMCID: 9839598 ; https://doi.org/10.1016/j.neurobiolaging.2022.11.007 |
Abstract | Hughes TF, Ran X, Fang F, et al. Psychosocial implications of early COVID-19 restrictions on older adults in a small-town region in Southwestern, Pennsylvania (USA) [published online ahead of print, 2022 Nov 10]. Int Psychogeriatr. 2022;1-10. PMID: 36352761; doi:10.1017/S1041610222000977 |
Abstract Full Article | Lee S, Jia Y, Snitz B, Chang C-C H, Ganguli M. Assessing social cognition in older adults: A population-based study. Alzheimer’s Disease and Associated Disorders, 2022. EPub doi: 10.1097/WAD.0000000000000497. PMID 35288520. PMC 9149050. |
2021 | |
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Abstract Full Article | Runk A, Jia Y, Liu A, Chang CH, Ganguli M, Snitz BE. Associations between Visual Acuity and Cognitive Decline in Older Adulthood: A 9-Year Longitudinal Study. J Int Neuropsychol Soc. 2023;29(1):1-11. PMID: 36630994; PMCID: 9834646; doi:10.1017/S1355617721001363 |
Abstract Full Article | Sullivan K, Ran X, Wu F, Chang C-C H, Sharma R, Jacobsen E, Berman S. Ambient fine particulate matter exposure and incident mild cognitive impairment and dementia. Journal of the American Geriatrics Society. PMID: 33904156; PMCID: 8373708; doi: https://doi.org/10.1111/jgs.17188 |
Abstract Full Article | Bhojak T, Jia Y, Jacobsen E, Snitz BE, Chang C-C H, Ganguli M. Driving Habits of older adults: A Population-Based Study. Alzheimer Disease and Associated Disorders. PMID: 33769988; PMCID: 8387314; DOI: 10.1097/WAD.0000000000000443 |
Abstract Full Article | Jacobsen, E., Ran, X., Liu, A., Chang, C. H., & Ganguli, M. (2021). Predictors of attrition in a longitudinal population-based study of aging. International psychogeriatrics, 33(8), 767–778. PMID: 32301414; PMCID: 7572515; doi: 10.1017/S1041610220000447 |
Abstract Full Article | Hughes TF, Liu A, Jacobsen E, et al. Exercise and the Risk of Mild Cognitive Impairment: Does the Effect Depend on Vascular Factors? Alzheimer Dis Assoc Disord. 2021;35(1):30-35; PMID: 32960854; PMCID9350907; doi:10.1097/WAD.0000000000000410 |
2020 | |
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Abstract Full Article | Ganguli M, Hughes TF, Jia Y, Lingler J, Jacobsen E, Chang CH. Aging and Functional Health Literacy: A Population-based Study [ePub ahead of print], 2020. Am J Geriatr Psychiatry. 2020;S1064-7481(20)30575-3. PMID: 33349506; doi:10.1016/j.jagp.2020.12.007 |
Abstract Full Article | Lee S, Jacobsen EP, Jia Y, Snitz BE, Chang CH, Ganguli M. Reading the Mind in the Eyes: A Population-Based Study of Social Cognition in Older Adults [ePub ahead of print]. Am J Geriatr Psychiatry. 2020;S1064-7481(20)30562-5. PMID: 33293250; PMCID: 8166961; doi:10.1016/j.jagp.2020.11.009 |
Abstract | Carles S, Carriere I, Reppermund S, et al., for Cohort Studies of Memory in an International Consortium (COSMIC). A cross-national study of depression in pre-clinical dementia: A COSMIC Collaboration Study. Alzheimer’s & Dementia, In press., PMC in process. |
Abstract Full Article | Sullivan KJ, Liu A, Chang CH, et al. Alzheimer's disease pathology in a community-based sample of older adults without dementia: The MYHAT neuroimaging study [ePub ahead of print]. Brain Imaging Behav. 2020;10.1007/s11682-020-00334-2. PMID: 32748322; PMCID: 7855234; doi:10.1007/s11682-020-00334-2 |
Abstract Full Article | Fan KH, Feingold E, Rosenthal SL, Demirci Y, Ganguli M, Lopez OL, Kamboh MI. Whole-Exome Sequencing (WES) Analysis of Alzheimer's Disease in Non-APOE*4 Carriers. Journal of Alzheimers Disease. 2020;76(4):1553-1565. PMID: 32651314; PMCID: 7484092; doi: 10.3233/JAD-200037 |
Abstract Full Article | Jia Y., Chang, C. C. H., Hughes, T. F., Jacobsen, E., Wang, S., Berman, S. B., Kamboh, M. I., & Ganguli, M. Predictors of Dementia in the Oldest Old: a Novel Machine Learning Approach. [ePub ahead of print]. Alzheimer Dis Assoc Discord.. 2020;10.1097; PMID: 32701513; PMCID: 7677183; doi: doi:10.1097/WAD.0000000000000400 |
Abstract Full Article | Cohen AD, Jia Y, Smagula S, Chang C-C H, Snitz B, Berman SB, Jacobsen EP, Ganguli M. Cognitive functions predict trajectories of sleepiness over ten years: A population-based study. [ePub ahead of print]. 2020; J Gerontol A Biol Sci Med Sci. PMID: 32405646; PMCID: 7907493; doi: 10.1093/gerona/glaa120; |
Abstract Full Article | Ganguli M, Beer JC, Zmuda JM, Ryan CM, Sullivan KJ, Chang, CC, Rao RH. Aging, diabetes, obesity, and cognitive decline: A Population-Based Study. [ePub ahead of print] Journal of the American Geriatrics Society. 2020;68(5):991-998. PMID: 32020605; PMCID: 8597580; doi: 10.1111/jgs.16321 |
Abstract Full Article | Stoehr GP, Jacobsen E, Jia Y, Snitz BE, Ganguli M. Trends in the use of medications and supplements to treat or prevent dementia: A population-based study. Alzheimer Disease and Associated Disorders. 2020;34(2):148-155. PMID: 31633558; PMCID: 7156330. doi: 10.1097/WAD.0000000000000357. |
Abstract Full Article | Peters R, Beers JC, Ganguli M, Anstey KJ. Investigation of antihypertensive class, dementia and cognitive decline. A meta-analysis. Neurology. 2020;94(3):e267-281. PMCID: 7108807; PMID: 31827004; doi: 0.1212/WNL.0000000000008732 |
Abstract Full Article | Sullivan KJ, Liu A, Dodge HH, Andreescu C, Chang CCH, Ganguli M. Depression Symptoms Declining Among Older Adults: Birth Cohort Analyses from the Rust Belt. American Journal of Geriatric Psychiatry. 2020; 28(1):99-107. PMID: 31300193 PMCID: 6898763; doi: 10.1016/j.jagp.2019.06.002 |
Abstract Full Article | Smagula SF, Jia Y, Chang CH, Cohen A, Ganguli M. Trajectories of daytime sleepiness and their associations with dementia incidence. Journal of Sleep Research. 2020; 29(6):e12952. PMID: 31782578; PMCID: 7253318; doi:10.1111/jsr.12952 |
2019 | |
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Abstract Full Article | Liu A, Sun Z, McDade E, Hughes TF, Ganguli M, Chang CH. Blood Pressure and Memory. Novel Approaches to Modeling Nonlinear Effects in Longitudinal Studies. Alzheimer Disease and Associated Disorders. 2019;33(4):291-298. PMID: 31567145; PMCID: 6878165. doi: 10.1097/WAD.0000000000000346 |
Abstract Full Article | Kamboh MI, Fan KH, Yan Q, Beer J, Snitz BE, Wang X, Chang CH, Demirci FY, Feingold E, Ganguli M. Population-based genome-wide association study of cognitive decline in older adults free of dementia: Identification of a novel locus for the attention domain. Neurobiology of Aging. 2019;84:239. PMID: 30954325; PMCID: 6739197; doi: 10.1016/j.neurobiolaging.2019.02.024 |
Abstract Full Article | Ganguli M, Jia Y, Hughes TF, Snitz BE, Chang CH, Berman SB, Sullivan KJ, Kamboh MI. Mild cognitive impairment that does not progress to dementia: A population-based study. Journal of the American Geriatrics Society. 2019;67(2):232-238. PMCID: 6367026; PMID: 30444944; doi: 10.1111/jgs.15642 |
Abstract Full Article | Sullivan KJ, Dodge HH, Hughes TF, Chang CH, Zhu X, Liu A, Ganguli M. Declining Incident Dementia Rates Across Four Population-Based Birth Cohorts. Journal of Gerontology Series A: Biological and Medical Sciences. 2019;74(9):1439-1445. PMID: 30312371; PMCID: 6696712; doi: 10.1093/gerona/gly236 |
2018 | |
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Abstract Full Article | Snitz BE, Wang T, Cloonan YK, Jacobsen E, Chang CH, Hughes TF, Kamboh MI, Ganguli M. Risk of progression from subjective cognitive decline to mild cognitive impairment: The role of study setting. Alzheimers & Dementia. 2018;14(6);734-742. PMID: 29352855; PMCID: 5994356; doi: 10.1016/j.jalz.2017.12.003 |
Abstract Full Article | Beer J, Snitz BE, Chang C-C H., Loewenstein D, Ganguli M. Does a cognitive stress test predict progression from mild cognitive impairment to dementia equally well in clinical versus population-based settings? International Psychogeriatrics. 2018;30(10):1435-1445. PMCID: 6047940; PMID: 29335040; doi: 10.1017/S1041610217002666 |
Abstract Full Article | Ganguli M, Sun Z, McDade E, Snitz BE, Hughes TF, Jacobsen E, Chang CC. That's Inappropriate! Social Norms in an Older Population-Based Cohort. Alzheimer Disease and Associated Disorders. 2018;32(2):150-155. PMCID: 5951726; PMID: 29140857; doi: 10.1097/WAD.0000000000000224 |
Abstract Full Article | Hughes TF, Sun Z, Chang CH, Ganguli M. Change in engagement in cognitive activity and risk for mild cognitive impairment in a cohort of older adults: The Monongahela-Youghiogheny Healthy Aging Team (MYHAT) study. Alzheimer Disease and Associated Disorders. 2018;32(2):137-144; PMID: 29028647; PMCID: 10317197; doi: 10.1097/WAD.0000000000000224 |
2017 | |
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Abstract Full Article | Dodge HH, Zhu J, Hughes TF, Snitz BE, Chang CH, Jacobsen EP, Ganguli M. Cohort effects in verbal memory function and practice effects: A population-based study. International Psychogeriatrics. 2017;29(1):137-148. PMCID: 5177461; PMID: 27725002; doi: 10.1017/S1041610216001551 |
2016 | |
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Abstract Full Article | McDade E, Sun Z, Lee CW, Snitz BE, Hughes T, Change CC, Ganguli M. The association between pulse pressure change and cognition in late life: Age and where you start matters. Alzheimer's & Dementia: Diagnosis, Assessment, and Disease Monitoring. 2016;4:55-66. PMCID: 4961825; PMID: 27489881; doi: 10.1016/j.dadm.2016.03.008 |
Abstract Full Article | Nimgaokar VL, Yolken RH, Wang T, Chang CC, McClain L, McDade E, Snitz BE, Ganguli M. Temporal cognitive decline associated with exposure to infectious agents in a population-based, aging cohort. Alzheimer Disease and Associated Disorders. 2016;30(3):216-222. PMCID: 4919236; PMID: 26710257; doi: 10.1097/WAD.0000000000000133 |
Abstract Full Article | Graziane JA, Beer JC, Snitz BE, Chang CC, Ganguli M. Dual trajectories of cognition and depression: A longitudinal population study. American Journal of Geriatric Psychiatry. 2016;24(5):364-373. PMCID: 4841743; PMID: 26560510; doi: 10.1016/j.jagp.2015.08.001 |
2015 | |
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Abstract Full Article | Snitz BE, Small BJ, Wang T, Chang CC, Hughes TF, Ganguli M. Do subjective memory complains lead or follow objective cognitive change? A Five-Year Population Study of Temporal Influence. Journal of the International Neuropsychological Society. 2015;21(9):732-42. PMCID: 4615611; PMID: 264776801; doi: 10.1017/S1355617715000922 |
Abstract Full Article | Hughes TF, Becker JT, Lee CW, Chang CC, Ganguli M. Independent and combined effects of cognitive and physical activity on incident MCI. Alzheimers and Dementia. 2015;11(11):1377-1384. PMCID: 4536189; PMID: 25684687; doi: 10.1016/j.jalz.2014.11.007 |
Abstract Full Article | Ganguli M, Lee C-W, Snitz BE, Hughes TF, McDade E, Chang C-CH. Rates and risk factors for progression to incident dementia vary by age in population cohort. Neurology. 2015;84(1):72-80. PMCID: 4336092; PMID: 25471390; doi: 10.1212/WNL.0000000000001113 |
Abstract Full Article | Ganguli M, Lee C-W, Hughes TF, Snitz BE, Jakubcak J, Duara R, Chang C-CH. Who wants a free brain scan? Assessing and correcting for recruitment biases in a population-based sMRI pilot study. Brain Imaging and Behavior. 2015;9(2):204-212. PMCID: 4147027; PMID: 24573773; doi: 10.1007/s11682-014-9297-9 |
2014 | |
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Abstract Full Article | Ganguli M, Lee C-W, Snitz BE, Hughes TF, McDade E, Chang CC. How well do MCI Criteria predict progression to severe cognitive impairment and dementia? Alzheimer Disease Associated Disorders. 2014;28(2):113-121. PMCID: 4040213; PMID: 24521821; doi: 10.1097/WAD.0000000000000018 |
Abstract Full Article | Hughes TF, Flatt JD, Fu B, Butters MA, Chang CC, Ganguli M. Interactive video gaming compared with health education in older adults with mild cognitive impairment: a feasibility study. International Journal of Geriatric Psychiatry. 2014;29(9):890-898. PMCID: 4326259; PMID: 24452845; doi: 10.1002/gps.4075 |
Abstract Full Article | Ganguli M, Fu B, Snitz BE, Unverzagt FW, Loewenstein DA, Hughes TF, Chang CC. Vascular risk factors and cognitive decline in a population sample. Alzheimer Disease and Associated Disorders. 2014;28(1):9-15. PMCID: 3945071; PMID: 24126216; doi: 10.1097/WAD.0000000000000004 |
Abstract Full Article | Andreescu C, Teverovsky E, Fu B, Hughes TF, Chang CC, Ganguli M. Old worries and new anxieties - behavioral symptoms and mild cognitive impairment in a population study. American Journal of Geriatric Psychiatry. 2014;22(3):274-284. PMCID: 3783616; PMID: 23759435; doi: 10.1016/j.jagp.2012.09.010 |
2013 | |
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Abstract Full Article | Ganguli M, Fu B, Snitz BE, Hughes TF, Chang CC. Mild cognitive impairment: incidence and vascular risk factors in a population-based cohort. Neurology. 2013;80(23):2221-2120. PMCID: 3716350; PMID: 23658380; doi: 10.1212/WNL.0b013e318295d776 |
Abstract Full Article | Hughes TF, Flatt JD, Fu B, Chang CC, Ganguli M. Engagement in social activities and progression from mild to severe cognitive impairment: The MYHAT study. International Psychogeriatrics. 2013;25(4):587-595. PMCID: 3578022; PMID: 23257280; doi: 10.1017/S1041610212002086 |
2012 | |
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Abstract Full Article | Becker JT, Duara R, Lee C-W, Teverovsky L, Snitz BE, Chang C-CH, Ganguli M. Cross-validation of brain structural biomarkers and cognitive aging in a community-based study. International Psychogeriatrics. 2012;24(7):1065-1075. PMCID: 3391579; PMID: 22420888; doi: 10.1017/S1041610212000191 |
Abstract Full Article | Snitz BE, Yu L, Crane PK, Chang CC, Hughes TF, Ganguli M. Subjective cognitive complaints of older adults at the population level: an Item Response Theory analysis. Alzheimer Disease and Associated Disorders. 2012;36(4):344-351. PMCID: 3337955; PMID: 22193355; doi: 10.1097/WAD.0b013e3182420bdf |
Abstract Full Article | Hughes TF, Chang C-CH, Vander Bilt J, Snitz BE, Ganguli M. Mild cognitive deficits and everyday functioning among older adults in the community: The Monongahela-Youghiogheny Healthy Aging Team (MYHAT) Study. American Journal of Geriatric Psychiatry. 2012;20(10):836-844. PMCID: 3445790; PMID: 22337146; doi: 10.1097/JGP.0b013e3182423961 |
2011 | |
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Abstract Full Article | Ganguli M, Snitz BE, Saxton JA, et al. Outcomes of mild cognitive impairment by definition: a population study. Archives of Neurology. 2011;68(6):761-767. PMCID: 3135309; PMID: 21670400; doi: 10.1001/archneurol.2011.101 |
Abstract Full Article | Weir, D. R., Wallace, R. B., Langa, K. M., Plassman, B. L., Wilson, R. S., Bennett, D. A., Duara, R., Loewenstein, D., Ganguli, M., & Sano, M. (2011). Reducing case ascertainment costs in U.S. population studies of Alzheimer's disease, dementia, and cognitive impairment-Part 1. Alzheimer's & dementia : the journal of the Alzheimer's Association, 7(1), 94–109. PMCID: 3044596; PMID: 21255747; doi: 10.1016/j.jalz.2010.11.004 |
2010 | |
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Abstract Full Article | Ganguli M, Vander Bilt J, Lee C-W, Snitz BE, Chang CC, Loewenstein DA, Saxton JA. Cognitive test performance predicts change in functional status at the population level: The MYHAT project. Journal of the International Neuropsychological Society. 2010;16(5):761-770. PMCID: 3232179; PMID: 20609270; doi: 10.1017/S1355617710000561 |
Abstract Full Article | Ganguli M, Chang C-CH, Snitz BE, Saxton JA, Vander Bilt J, Lee C-W. (2010). Prevalence of Mild Cognitive Impairment by multiple classifications. The Monongahela-Youghiogheny Healthy Aging Team (MYHAT) Project. American Journal of Geriatric Psychiatry. 2010;18(8):674-683. PMCID: 2906673; PMID: 20220597; doi: 10.1097/JGP.0b013e3181cdee4f |
Abstract Full Article | Snitz BE, Loewenstein DA, Chang CC, Lee C-W, Vander Bilt J, Saxton J, Ganguli M. A novel approach to assessing memory at the population level: Vulnerability to semantic interference. International Psychogeriatrics. 2010;22(5):785-794. PMCID: 2891858; PMID: 20105350; doi: 10.1080/13607860903071014 |
Abstract Full Article | Ganguli M, Snitz BE, Lee C-W, Vanderbilt J, Saxton JA, Chang CC. Age and education effects and norms on a cognitive test battery from a population-based cohort: The Monongahela-Youghiogheny Healthy Aging Team (MYHAT). Aging and Mental Health. 2010;14(1):100-107. PMCID: 2828360; PMID: 20155526; doi: 10.1080/13607860903071014 |
2009 | |
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Abstract Full Article | Snitz BE, Unverzagt FW, Chang CC, Vander Bilt J, Gao S, Saxton J, Hall KS, Ganguli M. Effects of age, gender, education, and race on two tests of language ability in community-based older adults. International Psychogeriatrics. 2009;21(6):1051-1062. PMCID: 2783556; PMID: 19586563; doi: 10.1017/S1041610209990214 |
Abstract Full Article | Ganguli M, Snitz B, Vander Bilt J, Chang CC. How much do depressive symptoms affect cognition at the population level? The Monongahela-Youghiogheny Healthy Aging Team (MYHAT) study. International Journal of Geriatric Psychiatry. 2009;24(11):1277-1284. PMCID: 2784260; PMID: 19340894; doi: 10.1002/gps.2257 |