- 2025
Abstract | Full Article | Acharya, V., Fan, K. H., Snitz, B. E., Ganguli, M., DeKosky, S. T., Lopez, O. L., Feingold, E., & Kamboh, M. I. (2025). Sex-stratified genome-wide meta-analysis identifies novel loci for cognitive decline in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association, 21(3), e14461. https://doi.org/10.1002/alz.14461. PMID: 40042063; PMCID: 11880917 Abstract | Full Article | Hughes TF, Song R, Wang Y, Jacobsen E, Chang C-C H, Ganguli M. The Impact of the COVID-19 Pandemic on Symptoms of Depression and Anxiety among Older Adults: The MYHAT Study. Aging and Mental Health, 2025 in press. PMC in process. - 2024
Abstract | Full Article | Zhang Y, Ferreira PCL, Jacobsen E, Bellaver B, Pascoal TA, Snitz BE, Chang C-C H, Villemagne VL, Ganguli M, Karikari T. Association of plasma biomarkers of Alzheimer’s disease and related disorders with cognition and cognitive decline: a population-based study. Alzheimer’s & Dementia, 2024, ePub doi: 10.1002/alz.13829. PMID 38753951, PMC in process. Abstract | Full Article | Research Poster | Wood IK, Song R, Zhang Y, Jacobsen E, Hughes T, Chang C-C H, Ganguli M. Ethno-racial identity and cognitive impairment: A community study. Alzheimer’s Disease and Associated Disorders, 2024, DOI 10.1097/WAD.0000000000000617, PMID 38748688, PMC: 11536525 - 2023
Abstract | Full Article | Teverovsky EG, Gildengers A, Ran X, Jacobsen E, Chang C-C H, Ganguli M. Benzodiazepine use and risk of incident MCI and dementia in a community sample. International Psychogeriatrics, 2023, ePub DOI: https://doi.org/10.1017/S1041610223000455 PMID 37231775, NIHMSID 1904514, PMCID: PMC10676448 Abstract | Full Article | Jain N, Wang Y, Zhang Y, Jacobsen E, Andreescu C, Snitz BE, Chang C-C H, Ganguli M. It goes both ways: The relationship between anxiety and mild cognitive impairment. International Journal of Geriatric Psychiatry, 2023, e5899, ePub http://doi.org/10.1002/gps.5899 PMID:36855309 PMCID: 11531759 Abstract | Full Article | Gildengers AG, Stoehr GP, Ran X, Jacobsen EP, Teverovsky EG, Chang C-C H, Ganguli M. Anticholinergic drug burden and risk of incident MCI and dementia –A Population-Based Study. Alzheimer’s Disease and Associated Disorders, 2022, DOI: 10.1097/WAD.0000000000000538, PMID: 36706325; PMCID 9974875 Abstract | Full Article | Wood I, Bhojak T, Jia Y, Jacobsen EP, Snitz BE, Chang C-C H, Ganguli M. Predictors of driving cessation in older adults: A 12-year population-based study. Alzheimer’s Disease and Associated Disorders, 2022, DOI: 10.1097/WAD.0000000000000541, PMID: 36706321; PMCID 9974810 Abstract | Full Article | Acharya V, Fan KH, Snitz BE, et al. Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19-related gene for global cognitive function [published online ahead of print, 2023 Apr 23]. Alzheimer's & Dementia: the journal of the Alzheimer's Association. 2023;10.1002/alz.13064. PMID: 37089073; PMCID 10590825; doi:10.1002/alz.13064 - 2022
Abstract | Full Article | Fan, K., Francis, L., Aslam, M. M., Bedison, M. A., Lawrence, E., Acharya, V., Snitz, B. E., Ganguli, M., DeKosky, S. T., Lopez, O. L., Feingold, E., & Kamboh, M. I. (2023). Investigation of the independent role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late-onset Alzheimer disease. Neurobiology of aging, 122, 107–111. PMID: 36528961; PMCID: 9839598 ; https://doi.org/10.1016/j.neurobiolaging.2022.11.007 Abstract | Full Article | Hughes TF, Ran X, Fang F, et al. Psychosocial implications of early COVID-19 restrictions on older adults in a small-town region in Southwestern, Pennsylvania (USA) [published online ahead of print, 2022 Nov 10]. Int Psychogeriatr. 2022;1-10. PMID: 36352761; doi:10.1017/S1041610222000977 Abstract | Full Article | Lee S, Jia Y, Snitz B, Chang C-C H, Ganguli M. Assessing social cognition in older adults: A population-based study. Alzheimer’s Disease and Associated Disorders, 2022. EPub doi: 10.1097/WAD.0000000000000497. PMID 35288520. PMC 9149050. - 2021
Abstract | Full Article | Runk A, Jia Y, Liu A, Chang CH, Ganguli M, Snitz BE. Associations between Visual Acuity and Cognitive Decline in Older Adulthood: A 9-Year Longitudinal Study. J Int Neuropsychol Soc. 2023;29(1):1-11. PMID: 36630994; PMCID: 9834646; doi:10.1017/S1355617721001363 Abstract | Full Article | Sullivan K, Ran X, Wu F, Chang C-C H, Sharma R, Jacobsen E, Berman S. Ambient fine particulate matter exposure and incident mild cognitive impairment and dementia. Journal of the American Geriatrics Society. PMID: 33904156; PMCID: 8373708; doi: https://doi.org/10.1111/jgs.17188 Abstract | Full Article | Bhojak T, Jia Y, Jacobsen E, Snitz BE, Chang C-C H, Ganguli M. Driving Habits of older adults: A Population-Based Study. Alzheimer Disease and Associated Disorders. PMID: 33769988; PMCID: 8387314; DOI: 10.1097/WAD.0000000000000443 Abstract | Full Article | Jacobsen, E., Ran, X., Liu, A., Chang, C. H., & Ganguli, M. (2021). Predictors of attrition in a longitudinal population-based study of aging. International psychogeriatrics, 33(8), 767–778. PMID: 32301414; PMCID: 7572515; doi: 10.1017/S1041610220000447 Abstract | Full Article | Hughes TF, Liu A, Jacobsen E, et al. Exercise and the Risk of Mild Cognitive Impairment: Does the Effect Depend on Vascular Factors? Alzheimer Dis Assoc Disord. 2021;35(1):30-35; PMID: 32960854; PMCID9350907; doi:10.1097/WAD.0000000000000410 - 2020
Abstract | Full Article | Sullivan KJ, Liu A, Chang CH, et al. Alzheimer's disease pathology in a community-based sample of older adults without dementia: The MYHAT neuroimaging study [ePub ahead of print]. Brain Imaging Behav. 2020;10.1007/s11682-020-00334-2. PMID: 32748322; PMCID: 7855234; doi:10.1007/s11682-020-00334-2 Abstract | Full Article | Jia Y., Chang, C. C. H., Hughes, T. F., Jacobsen, E., Wang, S., Berman, S. B., Kamboh, M. I., & Ganguli, M. Predictors of Dementia in the Oldest Old: a Novel Machine Learning Approach. [ePub ahead of print]. Alzheimer Dis Assoc Discord. 2020;10.1097; PMID: 32701513; PMCID: 7677183; doi: doi:10.1097/WAD.0000000000000400 Abstract | Full Article | Sullivan KJ, Liu A, Dodge HH, Andreescu C, Chang CCH, Ganguli M. Depression Symptoms Declining Among Older Adults: Birth Cohort Analyses from the Rust Belt. American Journal of Geriatric Psychiatry. 2020; 28(1):99-107. PMID: 31300193 PMCID: 6898763; doi: 10.1016/j.jagp.2019.06.002 Abstract | Full Article | Smagula SF, Jia Y, Chang CH, Cohen A, Ganguli M. Trajectories of daytime sleepiness and their associations with dementia incidence. Journal of Sleep Research. 2020; 29(6):e12952. PMID: 31782578; PMCID: 7253318; doi:10.1111/jsr.12952 Abstract | Full Article | Ganguli M, Hughes TF, Jia Y, Lingler J, Jacobsen E, Chang CH. Aging and Functional Health Literacy: A Population-based Study [ePub ahead of print], 2020. Am J Geriatr Psychiatry. 2020;S1064-7481(20)30575-3. PMID: 33349506; doi:10.1016/j.jagp.2020.12.007 Abstract | Full Article | Lee S, Jacobsen EP, Jia Y, Snitz BE, Chang CH, Ganguli M. Reading the Mind in the Eyes: A Population-Based Study of Social Cognition in Older Adults [ePub ahead of print]. Am J Geriatr Psychiatry. 2020;S1064-7481(20)30562-5. PMID: 33293250; PMCID: 8166961; doi:10.1016/j.jagp.2020.11.009 - 2019
Abstract | Full Article | Sullivan KJ, Dodge HH, Hughes TF, Chang CH, Zhu X, Liu A, Ganguli M. Declining Incident Dementia Rates Across Four Population-Based Birth Cohorts. Journal of Gerontology Series A: Biological and Medical Sciences. 2019;74(9):1439-1445. PMID: 30312371; PMCID: 6696712; doi: 10.1093/gerona/gly236 Abstract | Full Article | Shaaban CE, Jia Y, Chang C-C H, Ganguli M. Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study. International Psychogeriatrics, 2019; ePub doi: 10.1017/S1041610219001066 . PMID 31455442. PMC 6948010 - 2018
Abstract | Full Article | Beer J, Snitz BE, Chang C-C H., Loewenstein D, Ganguli M. Does a cognitive stress test predict progression from mild cognitive impairment to dementia equally well in clinical versus population-based settings? International Psychogeriatrics. 2018;30(10):1435-1445. PMCID: 6047940; PMID: 29335040; doi: 10.1017/S1041610217002666 - 2016
Abstract | Full Article | Graziane JA, Beer JC, Snitz BE, Chang CC, Ganguli M. Dual trajectories of cognition and depression: A longitudinal population study. American Journal of Geriatric Psychiatry. 2016;24(5):364-373. PMCID: 4841743; PMID: 26560510; doi: 10.1016/j.jagp.2015.08.001 - 2013
Abstract | Full Article | Hughes TF, Flatt JD, Fu B, Chang CC, Ganguli M. Engagement in social activities and progression from mild to severe cognitive impairment: The MYHAT study. International Psychogeriatrics. 2013;25(4):587-595. PMCID: 3578022; PMID: 23257280; doi: 10.1017/S1041610212002086 - 2012
Abstract | Full Article | Hughes TF, Chang C-CH, Vander Bilt J, Snitz BE, Ganguli M. Mild cognitive deficits and everyday functioning among older adults in the community: The Monongahela-Youghiogheny Healthy Aging Team (MYHAT) Study. American Journal of Geriatric Psychiatry. 2012;20(10):836-844. PMCID: 3445790; PMID: 22337146; doi: 10.1097/JGP.0b013e3182423961 - 2009
Abstract | Full Article | Hughes TF, Ganguli M. Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia. Curr Psychiatry Rev. 2009;5(2):73-92. PMID: 19946443; PMCID: 2782871; doi:10.2174/157340009788167347
*Dr. Hughes is supported by T32 award #MH019986 from the National Institute of Mental Health.